PFun Glucose Demo
Interactive simulation of circadian-ultradian glucose dynamics (over a 24-hour period)
A quick prelude...
(EDITED: 2025-08-19)
Before you launch into these results... I'll give you some extra special ~~~insider information~~~👀👀...🤫👀
I have another demo that's almost ready to show off...
Likely I'll have some time to write a sufficient blog post in the near future.
For now, I'll leave you with a tasty hint...
aRtIfIcIaL 🤖🚗 nEuRaL 🤖🚗 nEtWoRkS 🤖🚗...🚗🚗🚗... . 🤖🚪...🤸🤸🤸
~~~🤔🤔🤔...~~🫢~~~...🤫.~~🤭~~~~
An interactive biophysical simulation of glucose dynamics, estimated over a single 24-hour period. The curves shown represent: Meal-likelihood [0.0, 1.0], Glucose [0.0, 2.0], Insulin. This is a simplified version of the full model to avoid too much computational overhead (we're really maxing out Desmos here).
Things to try:
Try dragging the handles to modify the probability distribution for 'Breakfast', 'Lunch', 'Dinner'.
- To change a meal time, drag the handle horizontally along the x-axis.
- For meal sizes, drag vertically (y-axis).
Toggle/reset conditional parameters using the color-coded triangular buttons.
-
Click
'Toggle sleep-wake alignment"
to simulate metabolic syndrome conditions; expected shift in glucose metabolism.
| Color-coded Legend | |
|---|---|
| Meal probability density | The meal probability density defines the meal times and meal sizes. The center of the distribution is the estimated (most-likely) meal time. |
| Glucose | Normalized [0, 2] |
| Insulin | Responds within approximately 1-2 hours of a meal, at "baseline" metabolic health. Metabolic health is tightly interdependent with the circadian rhythm. |
Appendices
Other physio-functional simulations:
Good background reading:
- Glucose Demo
- PFun Glucose Chronometabolic Analysis Guide
- All figures are replicated from results cited in the Williams Textbook of Endocrinology .
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